Reversing Age with Science to Extend Longivity upto 100

By Michelle Roberts Health reporter, BBC News

Professor Eileen Ingham explains the main aims of the project

Science to 'stop age clock at 50'

1. Scientists have developed transplantable tissues the body can make its own, tackling rejection. They have made heart valves using the technique

2. A hip has been made from a durable alloy socket and ceramic ball that should last for life, rather than the current 20 years

3. Similar techniques are being developed for artificial knees

4. Eventually scientists hope to make ligaments and tendons to replace old and damaged ones

5. Artificial blood vessels are also being developed

6. The NHS is looking into using the transplantable tissue methods on donor skin for burns patients

7. Researchers also hope to do the same for organs

Centenarians with the bodies of 50-year-olds will one day be a realistic possibility, say scientists.

Half of babies now born in the UK will reach 100, thanks to higher living standards, but our bodies are wearing out at the same rate.

To achieve "50 active years after 50", experts at Leeds University are spending £50m over five years looking at innovative solutions.

They plan to provide pensioners with own-grown tissues and durable implants.

New hips, knees and heart valves are the starting points, but eventually they envisage most of the body parts that flounder with age could be upgraded.

The university's Institute of Medical and Biological Engineering has already made a hip transplant that should last for life, rather than the 20 years maximum expected from current artificial hips.

The combination of a durable cobalt-chrome metal alloy socket and a ceramic ball or "head" means the joint should easily withstand the 100 million steps that a 50-year-old can be expected to take by their 100th birthday, says investigator Professor John Fisher.

Meanwhile, colleague Professor Eileen Ingham and her team have developed a unique way to allow the body to enhance itself.

The concept is to make transplantable tissues, and eventually organs, that the body can make its own, getting round the problem of rejection.

So far they have managed to make fully functioning heart valves using the technique.

It involves taking a healthy donor heart valve - from a human or a suitable animal, such as a pig - and gently stripping away its cells using a cocktail of enzymes and detergents.

The inert scaffold left can be transplanted into the patient without any fear of rejection - the main reason why normal transplants wear out and fail.

Once the scaffold has been transplanted, the body takes over and repopulates it with cells.

Trials in animals and on 40 patients in Brazil have shown promising results, says Prof Ingham.

They have licensed the technology to the NHS National Blood and Transplant Tissue Services so it can be used on any UK donated human tissue in the future.

The NHS is already looking into using the method on donor skin for burns patients.

Professor Christina Doyle of Xeno Medical, the medical device company that is developing the technologies under Tissue Regenix, said the holy grail was to remove the heavy reliance on donor organs.

"That's where the technology will lead us eventually."

But she said: "To replace all donor tissue using this technology will take 30 to 50 years. Each single product will need to be designed and tested individually."

Prof Doyle said experts elsewhere were also working on similar regenerative therapies, but grown entirely outside of the body, to ensure that people can continue being as active during their second half-century as they were in their first.

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eBay Dropshipping

Ebay Dropshipper - the Real Source

Everyone and their mother is trying to start a business selling on ebay these days. The first thing you need to do is find a reliable ebay dropshipperThis will allow you to get the lowest possible prices from a great wholesaler. The best part is that by using dropshipping you won\'t have to store any inventory. Therefore, you only buy a product if your auction sells!

Using an ebay dropshipper may sound like something only a seasoned auction professional can do, but this is not true. You will learn how to successfully list and make your products sell. This company wants you to do well, because when you do well they do well and everybody wins. You will also benefit from this because you customer will end up paying less than they would anywhere else they might look.

What I like best about using an ebay dropshipper is that you know they are a certified dropshipping company and ebay realizes that. There are so many websites out there that claim to be a real dropshipper with the lowest prices. Many claim that you will make $1000 every week as soon as you start setting up auctions. It is not that simple and many of those websites do not offer the lowest price for every product. What it really comes down to is if you have the dedication to learn to create an auction business. There is more to it than just listing an item and collecting money.

To take full advantage of an ebay dropshipper you should do some research first. Find out what types of products are selling well and find out if the dropshipper you are looking at can provide you with those products. There are some websites that again claim to be a legitimate dropshipper but then end up being out of stock of a product you are selling or just take way too long to ship it to your customer. This is not good because many customers that will buy from you on ebay will want their item in a timely manner. The bottom line is to find a reliable source.

There are certain steps you can take to ensure that you find what products are hot and selling. You can use an ebay search function that will show you all listings that have already ended and what prices they have ended at. To utilize the ebay dropshipper you choose you must be able to find out what your products are worth in the market. To do this use ebay advanced search. Type in the name of the product you want to sell and make sure you checkmark the box that says include items that have already ended. This will show you about what price your product will sell for.

If you thought that you could just sign up with any old dropshipping website and start to make money then you may want to reconsider. Finding a legitimate ebay dropshipper can make your auction business a success. You will want to do research on every wholesale company you come across. This will ensure that you pick the right ebay dropshipper. We all know very well that there are many, many cheap products available from China. There are two sources listed with this ebay dropshipper and they will show you exactly how to do the transactions from start to finish. This is essential to your success. I am a huge fan of ebay and the best part about selling on ebay is that you don\'t need alot of money to get started, all you need is the best ebay dropshipperSince I have joined this company it has been nothing but profits. They are hands down the best company to go with if you plan on starting an auction business.

Author
Daniel St-jean

About Author

To jumpstart your auction business and get up to 90% off retail like I have visit: Ebay Dropshipper

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Nobel Prize to Indian Origin - V Ramakrishnan for Chemistry

Indian origin scientist V Ramakrishnan wins 2009 Chemistry Nobel

Tamil Nadu-born Venkatraman Ramakrishnan, a senior scientist at the MRC Laborartory of Molecular Biology at Cambridge, has been awarded the Nobel Prize [ Images ] in Chemistry for 2009 along with two others, the Nobel Committee announced on Wednesday.

Born in 1952 in Chidambaram, Ramakrishnan shares the Nobel prize with Thomas E Steitz (US) and Ada E Yonath (Israel) for their "studies of the structure and function of the ribosome".

Ramakrishnan earned his B.Sc. in Physics (1971) from Baroda University and his Ph.D. in Physics (1976) from Ohio University.

He moved into biology at the University of California, San Diego, where he took a year of classes, then conducted research with Dr Mauricio Montal, a membrane biochemist.

"This year's Nobel Prize in Chemistry awards Venkatraman Ramakrishnan, Thomas A Steitz and Ada E Yonath for having showed what the ribosome looks like and how it functions at the atomic level," the Nobel committee said in its citation.

All three have used a method called X-ray crystallography to map the position for each and every one of the hundreds of thousands of atoms that make up the ribosome, it said.

"This year's three Laureates have all generated 3D models that show how different antibiotics bind to the ribosome. These models are now used by scientists to develop new antibiotics, directly assisting the saving of lives and decreasing humanity's suffering," the citation said.

Better known as Venky among friends, Ramakrishnan started out as a theoretical physicist. After graduate school, he designed his own 2-year transition from physics to biology.

As a postdoctoral fellow at Yale University, he worked on a neutron-scattering map of the small ribosomal subunit of E Coli. He has been studying ribosome structure ever since.

Ramakrishnan has authored several important papers in academic journals.

In the August 26, 2000 issue of Nature, Ramakrishnan and his coworkers published the structure of the small ribosomal subunit of Thermus thermophilus, a heat-stable bacterium related to one found in the Yellowstone hot springs.

With this 5.5 Angstrom-resolution structure, Ramakrishnan's group identified key portions of the RNA and, using previously determined structures, positioned seven of the subunit's proteins.

In the September 21, 2000 issue of Nature, Ramakrishnan published two papers. In the first of these, he presents the 3 Angstrom structure of the 30S ribosomal subunit.

His second paper reveals the structures of the 30S subunit in complex with three antibiotics that target different regions of the subunit. In this paper, Ramakrishnan discusses the structural basis for the action of each of these drugs.

After his postdoctoral fellowship, Ramakrishnan joined the staff of Brookhaven National Laboratory in the US. There, he began his collaboration with Stephen White to clone the genes for several ribosomal proteins and determine their three-dimensional structures.

He was also awarded a Guggenheim fellowship during his tenure there, and he used it to make the transition to X-ray crystallography.

Ramakrishnan moved to the University of Utah in 1995 to become a professor in the Department of Biochemistry. There, he initiated his studies on protein-RNA complexes and the entire 30S subunit.

He since moved to the MRC Laboratory of Molecular Biology in Cambridge, where he is a Senior Scientist and Group Leader in the Structural Studies Division. He joins the list of several Nobel laureates who worked at the laboratory.

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Nobel for Discovery of Telomeres - The Immortal Enzyme

3 Americans win medicine Nobel for chromosome research

(CNN) -- Three U.S. researchers have won the Nobel Prize in physiology or medicine for solving "a major problem in biology," the Nobel Committee announced Monday.

Jack Szostak, from left, Carol Greider and Elizabeth Blackburn will share the $1.4 million prize.

Elizabeth H. Blackburn, Carol W. Greider and Jack W. Szostak are credited with discovering how chromosomes are protected against degradation -- a field that could shed light on human aging and diseases, including cancer.

"The award of the Nobel Prize recognizes the discovery of a fundamental mechanism in the cell, a discovery that has stimulated the development of new therapeutic strategies," the committee said in a news release.

The three will share the $1.4 million prize.

It is the 100th year the prize will be awarded, and the first time that any Nobel in the sciences has gone to more than one woman.

The work that won them the prize took place in the late 1970s and early 1980s.

It centers on structures at the end of chromosomes called telomeres and an enzyme that forms them, called telomerase.

As cells divide, chromosomes need to be replicated perfectly. Work by the researchers determined that telomeres protect DNA from degradation in the process, and that telomerase maintains the telomeres.

Though there had been some speculation that the three scientists were being considered for the Nobel, the committee keeps its work top secret -- and all three researchers said they were surprised.

Szostak told CNN he got the news in "that classic early morning phone call from Stockholm."

He described it as "surprising and exciting" -- perhaps particularly for him because he has not worked on the subject for the past 20 years. "I've been working on other things," he said. "It started off as a collaboration with me and Liz [Blackburn] -- Carol [Greider] was a student of hers."

The work began as "a long-standing puzzle that we were interested in solving," he said. "It was only over later years that it emerged, through the work of many people, that this was probably important for aging andcancer."

How it might help fight such diseases is not yet known, Szostak said. "It will take a while yet for that to be figured out."

Blackburn and Greider did not immediately return calls from CNN.

In a telephone conversation with the editor-in-chief of the Nobel Prize Web site nobelprize.org, Greider said she had been attracted to the field of research because "it seemed like the unanswered question."

She also said telomere research has a higher proportion of women than other fields because in its early days, the lead researchers brought women into the field. She called it a situation in which "you have someone that trains a lot of women and then there's a slight gravitation of women to work in the labs with other women."

She added, "I think actively promoting women in science is very important because the data has certainly shown that there has been an underrepresentation. And I think that the things that contribute to that are very many ... subtle, social kinds of things."

Blackburn, in a separate conversation posted on the Web site, said the proportion of women in telomere research is "fairly close to the biological ratio of men and women."

"It's all the other fields that are aberrant," she added, laughing.

The field of study intrigued her because "it's so intricate and complicated, and you want to know how it works," she said.

Blackburn was Greider's supervisor at the University of California, Berkeley. Now Blackburn is at the University of California, San Francisco. Greider is a professor at Johns Hopkins University School of Medicine in Baltimore, Maryland.

Szostak was previously at Harvard Medical School and is currently professor of genetics at Massachusetts General Hospital in Boston, Massachusetts.

Married with two children, he told CNN he has "no idea" what he'll do with his portion of the monetary prize -- about $467,000.

CNN asked whether he thinks his children, ages 9 and 12, will suddenly think dad's work is "really cool."

"Well," Szostak said, laughing, "maybe."

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Nobel Prize for Optical Fibre and Electronic Eye for Digital Camera Invention

3 win Nobel in physics for digital devices

Three scientists won the Nobel Prize in physics on Tuesday for two breakthroughs that led to two major underpinnings of the digital age -- fiber optics and digital photography, the Royal Swedish Academy of Sciences said.

Willard Boyle, left, and George Smith handle a charge-coupled device in 1974.

Charles K. Kao, a British and U.S. citizen, won for "groundbreaking achievements concerning the transmission of light in fibers for optical communication."

Willard S. Boyle, a Canadian and U.S. citizen, and George E. Smith, a U.S. citizen, "invented the first successful imaging technology using a digital sensor, a CCD (Charge-Coupled Device)."

Kao in 1966 "made a discovery that led to a breakthrough in fiber optics. He carefully calculated how to transmit light over long distances via optical glass fibers," the academy said in a press release.

Today, "optical fibers make up the circulatory system that nourishes our communication society" and "facilitate broadband communication such as the Internet," the academy said.

Don't Miss

• 3 Americans win Nobel Prize in medicine

Boyle and Smith's Charge-Coupled Device -- invented in 1969 -- "is the digital camera's electronic eye" and paved the way for digital photography.

"It revolutionized photography, as light could now be captured electronically instead of on film. The digital form facilitates the processing and distribution of these images. CCD technology is also used in many medical applications, e.g. imaging the inside of the human body, both for diagnostics and for microsurgery."

The Nobel Prizes are being awarded this week and next. The medicine award was handed out on Monday.

The prizes for chemistry and literature will be awarded Wednesday and Thursday. The Nobel Peace Prize winner will be named on Friday, and the award in economics will be issued on Monday.

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eBay Dropshipping - Start Your Own Home Business

Can Dropshipping Help My Ebay Business?

Author: JamesThomas

EBay is a great place to find bargains online, but did you know that it's also a great place for you to start your own work from home business? In fact, by using this guide to drop shipping, you'll find out just how simple it can be to earn cash from your living room!

eBay is an auction site that is popular throughout the world, but it's a particularly booming business in the USA. The great thing about it is that it's actually one of the easiest ways to start up a business, as all you have to do is create a listing for an item and watch as people bid on it. Unlike other businesses, eBay already has millions of customers, so you don't have to do your own marketing - in fact all you have to do is keep up with your eBay competition.

The main problem that people have when starting their eBay business is sourcing products to sell. It can be expensive to start up if you have to purchase bulk loads of different items and you're your somewhere to store them until they sell, but there are alternatives which you should consider that allow you to start your business for next to nothing and beat the prices of your eBay competition.

Drop shipping is the process that you need to know. As a guide to drop shipping and how it works, quite simply you will advertise products for sale that you are the property of your wholesale supplier. They will provide you with all the photos and details you need to create your listing, and once you have made a sale, you simply raise an order with your wholesaler, and you keep any profit you have made from the sale. It's a method which big sellers use to blow their eBay competition out of the water, and you can use it to.

One of the major benefits of using this guide to drop shipping is that you don't need any start up cash to get selling with your business. All you have to do is have access to the internet and the ability to create an eBay listing.

The hardest thing that you will have to do is find a reliable drop shipper. There are many people who advertise their services as being drop shippers, but in truth they are nothing more than companies looking to take advantage of you, and the exorbitant prices you will end up paying will not help beat your eBay competition.

In fact, as a guide to drop shipping reliably, your best bet is to find a good quality wholesale supplier that offers a drop shipping service. Trustworthy companies will be fully contactable, and have customer service assistants who are glad to be helping you. They will offer you the lowest prices available for your products which will help you ensure that you are making the best profits, and are able to survive against the eBay competition. A good quality wholesale drop shipper is your key to eBay success.

About the Author:

Author Bio:

WholesaleNewsletter.com
News and Sources for Wholesale Drop Shipping and Online Products Sourcing. Discover Drop Shipper Tips to Wholesale Marketing, and Finding Profitable Merchandise for Resell.

Article Source: ArticlesBase.com - Can Dropshipping Help My Ebay Business?

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India Agriculture and Food Management Survey

Agriculture -

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India Industry Survey Report 2008-2009

Industry -

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HD CamCorder How to Choose the Best HD Camcorder

Here is a wonderful article that explains the basic nitty-gritty in a HD Camcorder. The article has carefully weighed all the pros and cons for choosing the different types of HD Camcorder currently in the market.

If you are planning to buy a HD camcorder then this article would help you to make your choice as per requirement and temparament.

How to Choose the Best HD Camcorder

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Video Screen Recording and Market Presentation the Easy Way

Video Screen Recording of Presentation without Complex Editing

Video is proving to be a remarkable marketing tool on the net, which allows the webmaster to present his or her products and services to potential clients in an audio-visual mode.

In fact video on a website is the best way to enhance ones credibility. It instantly creates a rapport with the viewer and the person is better able to judge for oneself to the extent they could put their trust and money on the person and the website in whatever they have to offer.

Its trust and not fancy tempting products which is important to win the hearts and mind of the customers. No relationship can exist for lack of trust.

No wonder Video presentation is playing a big role in Internet Marketing.

Screen Video or Screencast

For video recording of presentation no fancy lights or video equipment is required. All you need is a simple Video screencast.

Here is how its all done.

Step 1: Video Recording

Allow five to seven seconds for each slide or animation to wait before moving to the following one. This is important since the brain cannot absorb quickly what appears on the screen as well as follow the audio running in the background at the same time. Hence the five to seven seconds of wait before proceeding to the next slide.

Also avoid piling up messages which would make it too jumbled up for the person to coordinate his eyes to read through the messages as well as listen to the audio commentary describing what the message is all about.

It is best to have one message at a time for each slide. This makes it easier for the brain to breathe easy as the person watching the video can assimilate the picture along with the single message as well as listen to the short commentary at a leisure pace.

Step 2: Audio Recording

After the video recording is all over you can start the audio recording.

Audio recording can be done with the help of a USB microphone.

By separately recording the audio, you can concentrate one at a time not both video and audio at the same time during recording.

Also there is no need to stop the video to rectify any mistake made while recording the audio, when you record the audio separately and not when you do the same along with video recording.

So start by playing the video. As each slide appears on screen, you make a comment on the picture and message being shown immediately. This is very similar to commenting on photos of your recent vacation which you show to your near and dear ones as and when it appears on screen.

So by making your comments in a relaxed and nice voice, you are better able to explain to your viewers what you have to show and drive the message to them. This helps to avoid speaking hurriedly when showing the video.

By maintaining a gap, of five to seven seconds before shifting to the next slide in the video, you have enough time to speak your thoughts aloud so that the viewer is better able to understand what he or she watches.

In case you need to speak more, then the gap between the slides could be increased to ten seconds at most.

Step 3: Synchronizing the video and audio using software

Software such as Camtasia helps to record the video and audio in separate layers, and accordingly set them to synchronize well with one another. You can move forward and backwards as per your will.

Since the video and audio are in two separate layers so in case any mistake crops up during video recording, you avoid re-shooting the screen video all over again. The same is true for audio too.

So go ahead and start shooting your screen video for your marketing presentation for your Internet surfers and viewers to win over their hearts and mind by your superb communication using screen video as your medium.

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Twitter India - India Climbs to Third Position as The Most Twittering Nation after Germany and USA

- By Somik Ranjan Roy

Indians traditionally are exceedingly noisy and communicative which at times turns to a roar and that's exactly happened in the virtual world too.

Having been placed in the ninth position way back in July by Sysomos in terms of volume shared by Indians for keying their thoughts to share with others on the Twitter.

In just two months India has climbed the third position as more Indians are joining the chorus to twitter more and more.

As per the internet users and traffic report by Alexa , India is now the third major contributor to the fastest growing Micro blogging site amongst Twitter Users according to Alexa.

8% of the total Twitter Users are from India, this despite only 7% of the population having access to the internet.

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Copenhagen Summit 2009 - 200 Pages Draft Prepared to Save The Earth by 190 Countries at Bangkok

by Somik Ranjan Roy

The world has increasingly become more concerned about the future of Earth's environment upon which depends the very survivability of humans and other living organisms that thrive on this planet, the only one so far amongst heavenly bodies, known to be inhabited because of the presence of the right environment on earth which is congenial to sustain living beings including humans.

As a good part of the globe is turning to automation and forests are being replaced by towns and cities, our dependability on fossil fuels has taken a quantum leap, which in turn has in the same proportion increased the carbon content in the air.

Since the denudation of forests on a large scale has resulted in non utilization of carbon-di-oxide an essential raw material for photosynthesis, the excess carbon-di-oxide remains in the air which in turn is causing the glass house effect i.e. sun radiation reflected back into the atmosphere by earth cannot escape the earths atmosphere, as a result of which the temperature continues to rise.

Scientists are of the opinion that even after taking all preventive measures the global temperature would soar to 3 degree Celsius.

If steps are not taken immediately for corrective measures, the temperature would rise beyond the prescribed threshold and cause terrible chaos and pathos on earth.

It is with the intention of a coordinated efforts between the members of the united nations, the Copenhagen Meet is being organised so that there is a meaningful efforts to contain the thermal content that envelops the earth.

The effect of Global warming is for all of us to see and experience, as polar caps begins to melt and ocean level is spilling over the coastal regions threatening to flood that is threatening not only human habitats as well as the large stretches of agricultural land, needed to feed the millions.

Here is a report on the 200 pages of draft that's being prepared and would be discussed in details for the first time by 190 countries who are assembling at Bangkok this week ahead of the Copenhagen Summit in December, to find ways and means as well as define roles for each category of nations, to reduce to confusion that's prevailing as well as the dispute between the developed and the developing countries such as China and India, two emerging Asian economic giants.

200 Pages to Save the World?

by David Adam

Draft agreement being discussed ahead of December's crucial Copenhagen summit is long, confusing and contradictory

Interactive: Beginner's guide to the negotiating text

It is a blueprint to save the world. And yet it is long, confusing and contradictory. Negotiators have released a draft version of a new global agreement on climate change, which is widely billed as the last chance to save the planet from the ravages of global warming.

Running to some 200 pages, the draft agreement is being discussed for the first time this week as officials from 190 countries gather in Bangkok for the latest round of UN talks. There is only one short meeting after this before they meet in Copenhagen aiming to hammer out a final version.

The draft text consolidates and reorders hundreds of changes demanded by countries to the previous version, which saw it balloon to an unmanageable 300 pages. It has no official status yet, and must be formally approved before negotiators can start to whittle it down. Here, we present key, edited sections from the text and attempt to decipher what the words mean.

The text includes sections on the traditional sticking points that have delayed progress on climate change for a decade or longer.

• How much are rich countries willing to cut their greenhouse gas emissions, and by when?

• Will large developing nations such as China make an effort to put at least a dent in their soaring levels of pollution?

• How much money must flow from the developed world to developing countries to grease the wheels and secure their approval? How much to compensate for the impact of past emissions, and how much to help prevent future emissions?

According to the UN rules, for a new treaty to be agreed, every country must sign up – a challenging requirement. The new treaty is designed to follow the Kyoto protocol, the world's existing treaty to regulate greenhouse gases, the first phase of which expires in 2012.

Because the US did not ratify Kyoto, the climate talks have been forced on to awkward parallel tracks, with one set of negotiations, from which the US is excluded, debating how the treaty could be extended past 2012. This new text comes from the second track, which lays out a plan to include all countries in long-term co-operative action.

Behind the scenes, pessimism about the Copenhagen talks is rising. Despite references in the text to a global goal and collective emission cuts of 25-40% by 2020 for rich countries, many observers believe there is little chance such an approach will succeed.

Stuart Eizenstat, who negotiated Kyoto for the US, said: "Copenhagen is more likely to be a way station to a final agreement, where each country posts the best that it can do... The key thing is let's not go into Copenhagen with all the same kind of guns blazing like we did in Kyoto."

A top European official told the Guardian: "We've moved on from the idea that we can negotiate on targets. That's naive and just not the way the deal will be done. The best we can get is that countries will put in what they want to commit to."

Once all the carbon offsets – buying pollution credits instead of cutting emissions – and "fudges" are taken into account, the outcome is likely to be that emissions in 2020 from rich countries will be broadly similar to those in 1990, he said. "That's really scary stuff."

Copenhagen climate change conference 2009

Climate change

Carbon emissions

United Nations

Kyoto protocol

Intergovernmental Panel on Climate Change (IPCC)

David Adam

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